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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACHE
All Species:
35.45
Human Site:
S378
Identified Species:
60
UniProt:
P22303
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22303
NP_000656.1
614
67796
S378
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
Chimpanzee
Pan troglodytes
XP_516857
643
72946
S407
V
Y
G
A
P
G
F
S
K
D
N
N
S
I
I
Rhesus Macaque
Macaca mulatta
NP_001121560
614
67754
S378
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
Dog
Lupus familis
XP_546946
611
67308
S375
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
Cat
Felis silvestris
Mouse
Mus musculus
P21836
614
68150
S378
V
Y
G
V
P
G
F
S
K
D
N
E
S
L
I
Rat
Rattus norvegicus
P37136
614
68178
S378
V
Y
G
V
P
G
F
S
K
D
N
E
S
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505841
602
68511
S366
V
Y
G
A
P
G
F
S
K
D
N
E
S
M
I
Chicken
Gallus gallus
P36196
767
83002
G533
V
Y
G
V
P
G
F
G
K
D
N
E
S
L
I
Frog
Xenopus laevis
NP_001121332
600
68177
S364
L
Y
G
A
P
G
F
S
K
N
N
E
S
L
I
Zebra Danio
Brachydanio rerio
Q9DDE3
634
71980
S365
L
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07140
649
71767
F418
L
Y
D
F
I
D
Y
F
D
K
D
D
A
T
A
Honey Bee
Apis mellifera
XP_393751
657
73886
F402
I
Y
Y
L
T
E
L
F
H
I
D
G
S
E
V
Nematode Worm
Caenorhab. elegans
P38433
620
71415
F365
I
F
P
V
A
D
F
F
T
K
T
D
F
I
K
Sea Urchin
Strong. purpuratus
XP_782113
508
56946
I304
R
T
R
E
V
T
Q
I
L
L
K
Q
F
E
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
99.5
92.8
N.A.
88.4
88.5
N.A.
50.6
47.9
59.6
60
N.A.
34.3
39.8
41.2
37.7
Protein Similarity:
100
66.8
99.6
96
N.A.
93
93.6
N.A.
68.2
58
73.4
73.6
N.A.
51.4
56.9
56.9
51.6
P-Site Identity:
100
86.6
100
100
N.A.
93.3
93.3
N.A.
93.3
86.6
86.6
93.3
N.A.
6.6
13.3
6.6
6.6
P-Site Similarity:
100
93.3
100
100
N.A.
93.3
93.3
N.A.
100
86.6
100
100
N.A.
40
33.3
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
50
8
0
0
0
0
0
0
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
15
0
0
8
65
15
15
0
0
0
% D
% Glu:
0
0
0
8
0
8
0
0
0
0
0
65
0
15
0
% E
% Phe:
0
8
0
8
0
0
79
22
0
0
0
0
15
0
0
% F
% Gly:
0
0
72
0
0
72
0
8
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
15
0
0
0
8
0
0
8
0
8
0
0
0
15
79
% I
% Lys:
0
0
0
0
0
0
0
0
72
15
8
0
0
0
8
% K
% Leu:
22
0
0
8
0
0
8
0
8
8
0
0
0
58
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
72
8
0
0
0
% N
% Pro:
0
0
8
0
72
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% Q
% Arg:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
65
0
0
0
0
79
0
0
% S
% Thr:
0
8
0
0
8
8
0
0
8
0
8
0
0
8
0
% T
% Val:
58
0
0
29
8
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
86
8
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _